Article 10320

Title of the article

A MODERN VIEW ON THE PROBLEM OF BIOLOGICAL EFFECTS OF RADIATION ON ALIVE ORGANISMS
(LITERATURE REVIEW) 

Authors

Gerasimova Tat'yana Vladimirovna, Senior lecturer, sub-department of dentistry, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: 26nfybnf86@mail.ru
Zyul'kina Larisa Alekseevna, Doctor of medical sciences, associate professor, head of the sub-department of dentistry, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: stomatologfs@yandex.ru
Mikulyak Nadezhda Ivanovna, Doctor of medical sciences, associate professor, head of the sub-department of human physiology, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: normphys@mail.ru
Kavtaeva Galina Grigor'evna, Assistant, sub-department of dentistry, Medical Institute, Penza StateUniversity (40 Krasnaya street, Penza, Russia), E-mail: stomatologfs@yandex.ru
Zinov'ev Aleksandr Ivanovich, Candidate of medical sciences, head of the radiological department, Regional Oncological Dispensary (37A Stroiteley av enue, Penza, Russia), E-mail: stomatologfs@yandex.ru 

Index UDK

616-092

DOI

10.21685/2072-3032-2020-3-10 

Abstract

The current state of the radiation effect issue on living organisms is analyzed. The biological effects caused by ionizing radiation in low doses are considered. Radiation hormesis and the phenomenon of the adaptive response were noted as positive effects of the latter. Studies are presented that the risk of oncological diseases increases after exposure to acute radiation at doses above 50 mGy or chronic ata dose of 100 mGy. The review reflects the problems associated with finding quantitative indications for the timely initiation of therapy in persons exposed to lifethreatening doses of radiation, as well as effective triage tools for providing first aid in case of massive radiological incidents. Particular attention is paid to the analysis of research results confirming the ability of ionizing radiation to accelerate aging in the tissues of living organisms. Revealed the ambiguity of researchers' opinions on a number of issues related to the use of ionizing radiation in medicine, in particular in the form of X-ray and radionuclide diagnostics. 

Key words

radiation, acute radiation sickness, radiation risk, radiotherapy, radiosensitivity 

Download PDF
References

1. Aleksakhin R. M. Problemy radioekologii: evolyutsiya idey. Itogi [Radioecology problems: evolution of ideas. Outcome]. Moscow: Rossel'khozakademiya GNU VIIISKhRAE, 2006, 880 p. [In Russian]
2. Buldakov L. A., Kalistratova V. S. Radiatsionnoe vozdeystvie na organizm - polozhitel'nye effekty [Radiation effects on the body - positive effects]. Moscow: Inform- Atom, 2005, 246 p. [In Russian]
3. Velichkovskiy B. T. Vzaimosvyaz' sotsial'nykh i biologicheskikh mekhanizmov v razvitii demograficheskogo krizisa i izmeneniy zdorov'ya naseleniya Rossii [The relationship between social and biological mechanisms in the development of the demographic crisis and changes in the health of the population of Russia]. Moscow: RAMN, 2012, 255 p. [In Russian]
4. Gus'kova A. K. Atomnaya otrasl' strany glazami vracha [The country's nuclear industry through the eyes of a doctor]. Moscow: Real'noe vremya, 2004, 240 p. [In Russian] 5. Danilov P. V., Zhiganov K. V., Pronin A. V. Molodoy uchenyy [Young scientist]. 2016, no. 23 (127), pp. 40–44. [In Russian]
6. Popov E. V., Panteleev V. A., Segal' M. D., Gavrilov S. L., Ovsyanik A. I., Lysenko I. A. Tekhnologii tekhnosfernoy bezopasnosti [Technosphere safety technologies]. 2019, no. 3 (85), pp. 115–126. [In Russian]
7. Baranov A. E., Petrosyan L. N., Pyatkin E. K. et al. Meditsinskaya radiologiya [Medical radiology]. 1977, vol. 22, no. 8, pp. 48–55. [In Russian]
8. Morgan W. F., Bair W. J. A perspective. Radiat. Res. 2013, vol. 179, no. 5, pp. 501–510.
9. Burlakova E. B., Erokin V. N., Semenov V. A. Radiatsionnaya biologiya. Radioekologiya [Radiation biology. Radioecology]. 2006, vol. 46, no. 5, pp. 527–530. [In Russian]
10. Galstyan I. A., Nadezhina N. M. Meditsinskaya radiologiya i radiatsionnaya bezopasnost' [Medical radiology and radiation safety]. 2012, vol. 57, no. 5, pp. 31–36. [In Russian]
11. Davydov M. I., Gantsev Sh. Kh. Onkologiya: uchebnik [Oncology: textbook]. Moscow: GEOTAR Media, 2010, 920 p. [In Russian]
12. Pearce M. S., Salotti J. A., Little M. P., McHugh K., Lee C., Kim K. P., Howe N. L., Ronckers C. M., Rajaraman P., Sir Craft A. W., Parker L. Berrington de Gonzalez A. Lancet. 2012, vol. 380, no. 9840, pp. 499–505.
13. Federal'nyy proekt «Bor'ba s onkologicheskimi zabolevaniyami» Postanovlenie Pravitel'stva RF ot 26.12.2017 № 1640 (red. ot 30.11.2019) «Ob utverzhdenii gosudarstvennoy programmy Rossiyskoy Federatsii «Razvitie zdravookhraneniya» (s izm. i dop., vstup. v silu s 01.01.2020) [Federal project “Fight against oncological diseases” Resolution of the Government of the Russian Federation of November 26, 2017 (as amended on November 30, 2019) “On the approval of the state program of the Russian Federation "Development of health care” (with changes and additions from January 1, 2020)]. [In Russian]
14. Davydov M. I., Aksel' E. M. Evraziyskiy onkologicheskiy zhurnal [Eurasian oncological journal]. 2016, vol. 4, no. 4, pp. 692–879. [In Russian]
15. Danilov P. V., Zhiganov K. V., Pronin A. V. Molodoy uchenyy [Young scientist]. 2016, no. 23 (127), pp. 40–44. [In Russian]
16. Tkachev S. I., Nechushkin M. I., Yur'eva T. V. Vestnik Rossiyskoy akademii meditsinskikh nauk [Bulletin of the Russian Academy of Medical Sciences]. 2011, no. 12, pp. 34–40. [In Russian]
17. Keirim-Markus I. B. Meditsinskaya radiologiya i radiatsionnaya bezopasnost' [Medical radiology and radiation safety]. 1997, vol. 42, no. 2, pp. 18–25. [In Russian]
18. Klimanov V. A. Radiobiologicheskoe i dozimetricheskoe planirovanie luchevoy i radionuklidnoy terapii. Chast' 2. Luchevaya terapiya puchkami protonov, ionov, neytronov i puchkami s modulirovannoy intensivnost'yu, stereotaksis, brakhiterapiya, radionuklidnaya terapiya, optimizatsiya, garantiya kachestva: ucheb. posobie [Radiobiological and dosimetric planning of radiation and radionuclide therapy. Part 2. Radiation therapy with beams of protons, ions, neutrons and beams with modulated intensity, stereotaxis, brachytherapy, radionuclide therapy, optimization, quality assurance: teaching aid]. Moscow: Niyaumifi, 2011, 604 p. [In Russian]
19. Trofimova O. P., Tkachev S. P., Yur'eva T. V. Klinicheskaya onkogematologiya. Fundamental'nye issledovaniya i klinicheskaya praktika [Clinical hematology oncology. Basic research and clinical practice]. 2013, vol. 6, no. 4, pp. 355–364. [In Russian]
20. Andreassen C. N., Alsner J. Radiother Oncol. 2009, vol. 92, no. 3, pp. 299–309.
21. Trufanov G. E., Asaturyan M. A., Zharinov G. M. Luchevaya terapiya [Radiation therapy]. Moscow: GEOTAR-Media, 2007, vol. 2, 195 p. [In Russian]
22. Vorob'ev A. I. Terapevticheskiy arkhiv [Therapeutic archive]. 1986, no. 12, pp. 3–8. [In Russian]
23. Vanina E. A., Tseluyko S. S., Voytsekhovskiy V. V. Amurskiy meditsinskiy zhurnal [Amur medical journal]. 2014, no. 1 (5), pp. 80–87.
24. Pustovalova M. V., Grekhova A. K., Osipov A. N. Radiatsionnaya biologiya. Radioekologiya [Radiation biology. Radioecology]. 2018, vol. 58, no. 4, pp. 352–362. [In Russian]
25. Avetisov G. M., Barabanova A. I., Grachev M. I. Mestnye luchevye porazheniya u naseleniya: diagnostika i lechenie [Local radiation injuries in the population: diagnosis and treatment]. Moscow: VTsMK «Zashchita», 2001, 59 p. [In Russian]
26. Stozharov A. N. Radiatsionnaya meditsina [Radiation medicine]. Minsk: BGMU, 2007, 144 p. [In Russian]
27. Goans R. E., Felynn D. F. Medical Consequences of Radiological and Nuclear Weapons. USA, 2013, pp. 19–35.
28. Avetisov G. M., Vladimirov V. G., Goncharov S. F., Legeza V. I., Selidovkin G. D. Sindromy ostroy luchevoy bolezni. Klinicheskie proyavleniya, profilaktika i lechenie [Acute radiation sickness syndromes. Clinical manifestations, prevention and treatment]. Moscow: VTsMK «Zashchita», 2003, 244 p. [In Russian]
29. Grigor'ev A. Yu. Individual'naya radiochuvstvitel'nost' [Individual radio sensitivity]. Moscow: Meditsina, 1991, 80 p. [In Russian]
30. Zhadan S. A., Vismont F. I., Melenchuk E. V. Povrezhdayushchee deystvie ioniziruyushchey radiatsii [The damaging effect of ionizing radiation]. Minsk: BGMU, 2016, 28 p. [In Russian]
31. Stepanov A. V., Lyubin A. V., Perepelitsyn N. I., Tarasova O. A., Malezhik M. S. Meditsinskaya zashchita pri radiatsionnykh i toksikologicheskikh porazheniyakh [Medical protection for radiation and toxicological injuries]. Chita: IITs ChGMA, 2011, 242 p. [In Russian]
32. Tsygan V. N., Kazachenko A. I., Kuprava M. V. Patofiziologiya luchevoy bolezni [Pathophysiology of radiation sickness]. Saint-Petersburg, 2017, 63 p. [In Russian]
33. Hannah R. Wardill., Joanne M. B., Rachel J. G. Expert Opin Biol Ther. 2012, vol. 70, no. 5, pp. 627–635.
34. Stephen S. T., Elting L. S., Keefe D., Peterson D. E., Schubert M., Hauer‐Jensen M., Bekele N., Raber‐Durlacher J., Donnelly P., Rubenstein E. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2004, vol. 100, no. S9, pp. 1995–2025.
35. Panchenko A. V., Tyndyk M. L., Fedoros E. I., Maydin M. A., Semenov A. L., Gubareva E. A., Golubev A. G., Anisimov V. N. Uspekhi gerontologii [Advances in gerontology]. 2019, vol. 32, no. 3, pp. 325–330. [In Russian]
36. Akleev A. V., Veremeeva G. A., Vozilova A. V. Radiatsionnaya biologiya. Radioekologiya [Radiation biology. Radioecology]. 2006, vol. 46, no. 5, pp. 519–526. [In Russian]
37. Vanina E. A., Tseluyko S. S., Voytsekhovskiy V. V. Amurskiy meditsinskiy zhurnal [Amur medical journal]. 2014, no. 1 (5), pp. 80–87. [In Russian]
38. Alferova T. M., Tronov V. A., Soldatenkov V. A. Radiobiologiya [Radiobiology]. 1988, no. 4, pp. 441–447. [In Russian]
39. Dubinin N. P., Dubinina L. G., Tarasov V. A. Genetika [Genetics]. 1965, no. 1 (5), pp. 68–80. [In Russian]
40. Tronov V. A., Grin'ko E. V., Konchalovskiy M. V., Danilova N. B., Tereshchenko D. G., Filippovich I. V. Meditsinskaya radiologiya [Medical radiology]. 1993, vol. 38, no. 2, pp. 38–41. [In Russian]
41. Akagi Y., Ito K., Sawada S. Int. J. Radiat. Biol. 1993, vol. 64, no. 1, pp. 47–56.
42. Pathol A. Lab. Med. Toxicol Pathol. 2007, vol. 35, no. 4, pp. 495–516.
43. Baverstock K. Int. J. Environ. Res. Public Health. 2013, vol. 9, pp. 1356–1377.
44. Kovan'ko E. G. Fluorestsentnaya kharakteristika izmeneniy struktury DNK kletok krovetvornoy sistemy obluchennykh krys: avtoref. dis. kand. biol. nauk [Fluorescence characteristics of changes in the DNA structure of cells of the hematopoietic system of irradiated rats: author's abstract of dissertation to apply for the degree of the candidate of biological sciences]. Saint-Petersburg, 1999, pp. 19–31. [In Russian]
45. Galstyan I. A., Nugis V. Yu., Suvorova L. A., Nadezhina N. M., Davtyan A. A., Nikitina V. A., Kozlova M. G., Dubovoy D. A., Dobrovol'skaya E. I., Khvostunov I. K., Golub E. V. Meditsina truda i promyshlennaya ekologiya [Occupational medicine and industrial ecology]. 2017, no. 4, pp. 56–62. [In Russian]
46. Shevchenko T. S. Issledovanie strukturno-funktsional'nykh pokazateley kletok krovi sel'skokhozyaystvennykh zhivotnykh pri deystvii ioniziruyushchikh izlucheniy i indikatsiya na ikh osnove radiatsionnykh porazheniy: dis. kand. biol. nauk [Study of structural and functional parameters of blood cells of agricultural animals under the action of ionizing radiation and indication on their basis of radiation damage: dissertation to apply for the degree of the candidate of biological sciences]. Obninsk, 2000, pp. 17–22. [In Russian]
47. Sevbitov A. V., Skatova E. A. Stomatologiya [Dentistry]. 2005, no. 2, pp. 15–20. [In Russian]
48. Yablokova N. A., Sevbitov A. V. Rossiyskiy vestnik perinatologii i pediatrii [Russian bulletin of perinatology and pediatrics]. 2012, no. 6, pp. 82–87. [In Russian]
49. Fagiolo U. et al. Eur. J. Immunol. 1993, vol. 23, no. 9, pp. 2375–2378.
50. Rudolph R. et al. Plast. Reconstr. Surg. 1988, vol. 82, no. 4, pp. 669–677.
51. Cortese F., Klokov D., Osipov A., Stefaniak J., Moskalev A., Schastnaya J., Cantor C., Aliper A., Mamoshina P., Ushakov I., Sapetsky A., Vanhaelen Q., Alchinova I., Karganov M., Kovalchuk O., Wilkins R., Shtemberg A., Moreels M., Baatout S., Izumchenko E., de Magalhães J. P., Artemov A. V., Costes S. V., Beheshti A., Mao X. W., Pecaut M. J., Kaminskiy D., Ozerov I. V., Scheibye-Knudsen M., Zhavoronkov A. Oncotarget. 2018, vol. 9, no.18, pp. 14692–14722.
52. Ossetrova N. I., Ney P. H., Condliffe D. P., Krasnopolsky K., Hieber K. P. Health Phys. 2016, vol. 111, no. 2, pp.134–144.
53. Bushmanova A. Yu. Radiatsionnye porazheniya cheloveka [Human radiation damage]. Moscow: Slovo, 2007, 176 p. [In Russian]
54. Yablokova N. A., Sipyagina A. E., Sevbitov A. V. Dental Forum. 2013, no. 2, pp. 34–36.
55. Grekhova A. K., Pustovalova M. V., Eremin P. S., Ozerov I. V., Maksimova O. A., Gordeev A. V., Vorob'eva N. Yu., Osipov A. N. Radiatsionnaya biologiya. Radioekologiya. [Radiation biology. Radioecology.]2018, vol. 58, no. 6, pp. 590–597. [In Russian]
56. Kuzin A. M. Radiobiologiya [Radiobiology]. 1991, vol. 31, no. 1, pp. 16–21. [In Russian]
57. Osipov A., Andreyan N., Pustovalova M., Grekhova A., Eremin P., Vorobyova N., Pulin A., Zhavoronkov A., Roumiantsev S., Klokov D., Eremin I. Oncotarget. 2015, vol. 6, pp. 275–287.
58. Osipov A., Pustovalova M., Grekhova A., Eremin P., Vorobyeva N. Seventh international conference on radiation in various fields of research book of abstracts. 2019, p. 380.

 

Дата создания: 19.10.2020 12:58
Дата обновления: 20.10.2020 11:33